Depression and sleep disorders are associated with early mortality in women with breast cancer in the United Kingdom
| Autor: | Karel Kostev, Laura Bach, Matthias Kalder |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Sleep Wake Disorders
Pediatrics medicine.medical_specialty Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer medicine Insomnia Humans Biological Psychiatry Depression (differential diagnoses) Retrospective Studies Depression Proportional hazards model business.industry Mortality rate Retrospective cohort study Middle Aged medicine.disease Sleep in non-human animals United Kingdom 030227 psychiatry Psychiatry and Mental health Female medicine.symptom business 030217 neurology & neurosurgery Anxiety disorder |
| Zdroj: | Journal of Psychiatric Research. 143:481-484 |
| ISSN: | 0022-3956 |
| Popis: | Background The aim of this study was to estimate the association between common mental disorders and mortality in breast cancer patients. Methods This retrospective cohort study included women aged 18–80 for whom an initial diagnosis of breast cancer was documented in one of 200 general practices in the UK between January 2008 and December 2012. The main outcome of this study was the mortality within 5 years of the index date as a function of depression, anxiety disorder, and sleep disorders, using Cox regression models. Results A total of 6656 women (mean age: 57.9 (standard deviation: 12.0 years)) were included in the study. Within 5 years of the index date, 461 (6.9%) of women were deceased. Depression (HR: 1.44 (95% CI: 1.17–1.78)), and sleep disorders (HR: 1.37 (95% CI: 1.02–1.84)) were significantly associated with death within 5 years. Conclusions It is important to treat BC patients with chronic diseases holistically and to take psychological comorbidities seriously as factors influencing the survival of patients in order to counteract the considerable mortality rate of BC patients. |
| Databáze: | OpenAIRE |
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