Autor: |
Peter E. McDermott, Martin P. Ó. Fearraigh, Alexandra M. Horan, Eoghan M. McGarrigle |
Rok vydání: |
2023 |
Předmět: |
|
Zdroj: |
Organicbiomolecular chemistry. |
ISSN: |
1477-0539 |
Popis: |
Thiourea catalysts activated α,β-unsaturated phosphonates and phosphinates toward conjugate addition by amines to give β-aminophosphonates and β-aminophosphinates. The organocatalytic methodology was used to synthesise 15 β-aminophosphonates and -phosphinates in yields up to 99%. A gram-scale example furnished the corresponding β-aminophosphonate in an isolated yield of 99% with 97% catalyst recovery. Based on mechanistic experiments, hydrogen bonding between the phosphoryl oxygen and thiourea are proposed to play a crucial role in substrate activation. |
Databáze: |
OpenAIRE |
Externí odkaz: |
|