Effect of antipsychotic treatment on Insulin-like Growth Factor-1 and cortisol in schizophrenia: a longitudinal study
| Autor: | Bangalore N. Gangadhar, Taranath K. Shetty, Seetharamaiah Chittiprol, Ganesan Venkatasubramanian, Narendran Neelakantachar |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Hypothalamo-Hypophyseal System Hydrocortisone medicine.medical_treatment Statistics as Topic India Pituitary-Adrenal System Context (language use) Insulin-like growth factor Reference Values Internal medicine medicine Humans Longitudinal Studies Insulin-Like Growth Factor I Antipsychotic Biological Psychiatry Psychiatric Status Rating Scales medicine.disease Psychiatry and Mental health Endocrinology Hypercortisolemia Schizophrenia Female Schizophrenic Psychology Psychology Glucocorticoid medicine.drug Antipsychotic Agents |
| Zdroj: | Schizophrenia research. 119(1-3) |
| ISSN: | 1573-2509 |
| Popis: | Neurodevelopmental pathogenesis of schizophrenia might be mediated by abnormalities in Insulin-like Growth Factor-1 (IGF-1). Developmental disturbances like obstetric complications, by themselves, as well as through the resultant hypercortisolemia due to hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, can lead to deficient IGF-1 level. The relevance of IGF-1-Cortisol interactions in schizophrenia, especially in the context of antipsychotic treatment, is yet to be explored. In this study, thirty-three antipsychotic-naive schizophrenia patients (13-men) were examined for serum IGF-1 and cortisol levels at baseline and after 3months of antipsychotic treatment. For baseline analyses, the patients were compared with 33 healthy controls matched for age, sex, socio-economic status, and physical activity. Symptoms were assessed using Scale for Assessment of Positive Symptoms (SAPS) and Scale for Assessment of Negative Symptoms (SANS). At baseline, schizophrenia patients had significantly lower levels of IGF-1 [t=4.6; p |
| Databáze: | OpenAIRE |
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