Brain haemorrhage in five infants with coagulopathy
| Autor: | P Anslow, David Keeling, H Bilolikar, G Haythornthwaite, M T McShane, E B A Vorstman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Case Report Central nervous system disease alpha 1-Antitrypsin Deficiency Alagille syndrome Vitamin K deficiency Coagulopathy medicine Humans education education.field_of_study Alpha 1-antitrypsin deficiency business.industry Vascular disease Infant Newborn Infant Blood Coagulation Disorders medicine.disease Surgery Alagille Syndrome Pediatrics Perinatology and Child Health Coagulation screen Female Vitamin K Deficiency Tomography X-Ray Computed business Complication Intracranial Hemorrhages |
| Zdroj: | Archives of Disease in Childhood. 88:1119-1121 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.88.12.1119 |
| Popis: | Most intracranial haemorrhages in infants after the neonatal period are secondary to non-accidental injury. Occasionally brain haemorrhages in non-mobile infants are due to an inherited coagulopathy. This may often be diagnosed with a coagulation screen on admission. Little is known about the neurological outcome of infants in the latter group. Five infants are described who presented with acute spontaneous brain haemorrhage secondary to an inherited coagulopathy (n = 3) and vitamin K deficiency in alpha(1) antitrypsin deficiency (n = 1) and Alagille's syndrome (n = 1). Despite the critical clinical presentation and the severe imaging findings, these five infants made a good neurological recovery. Infants presenting with spontaneous ICH due to a significant (inherited) coagulopathy are usually easy to differentiate from non-accidental shaking injury; their bleeding pattern within the brain seems different from non-accidental shaking injury and neurodevelopment outcome appears better. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|