Pre-implantation genetic testing: decisional factors to accept or decline among in vitro fertilization patients
| Autor: | Maya Sabatello, Shawn Gurtcheff, Alena Wilson, Erin Rothwell, Erica Johnstone, Melinda Bonnie Fagan, Amber Mathiesen, Erin Johnson, Naomi Riches, Leslie P. Francis, Isabella Canada, Brandy Lamb |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Reproductive Techniques Assisted medicine.medical_treatment media_common.quotation_subject Decision Making Reproductive medicine Fertilization in Vitro 03 medical and health sciences 0302 clinical medicine Optimism Pregnancy medicine Genetics Humans Embryo Implantation Genetic Testing Pregnancy termination Genetics (clinical) Preimplantation Diagnosis media_common Genetic testing 030219 obstetrics & reproductive medicine In vitro fertilisation medicine.diagnostic_test business.industry Pregnancy Outcome Obstetrics and Gynecology General Medicine medicine.disease Aneuploidy 030104 developmental biology Reproductive Medicine Family medicine Decision support tools Female business Carrier screening Developmental Biology Maternal Age |
| Popis: | PURPOSE: Embryo testing to improve pregnancy outcomes among individuals who are seeking assisted reproduction technologies is increasing. The purpose of this study was to assess decisional factors through in-depth interviews for why women would accept or decline preimplantation genetic testing for aneuploidy (PGT-A) with in vitro fertilization (IVF). METHODS: Semi-structured telephone interviews were conducted with 37 women who were offered PGT-A with IVF during the summer 2017. Interviews lasted on average 40 min and were audio-recorded, transcribed, and analyzed using a content analysis. RESULTS: Results identified a number of decisional factors related to values about conception, disability, and pregnancy termination, past pregnancy experiences, optimism toward technology, and cost. Other key issues that were identified include the use of expanded carrier screening prior to IVF, maternal age, and limited education about PGT-A due to the complexity about education for IVF alone. CONCLUSION: There is a need to develop decision support tools for the increasing choices of genetic testing options for patients seeking IVF. Including patients’ values, past pregnancy experiences and attitudes toward science into the decision-making process may help promote a more informed decision. |
| Databáze: | OpenAIRE |
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