Lung Function and Methacholine Responsiveness among Adolescents in an Air-Polluted Area
| Autor: | Gianni Tognoni, Emanuela Giacomotti, Simona Barlera, Erminio Longhini, Patrizia Palmulli, Paolo Fanari, Marina Gabrione, Alberto Salvadori, Daniela Gori |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Adolescent Airway hyperresponsiveness Bronchial Provocation Tests Age Distribution Risk Factors ABO blood group system parasitic diseases medicine Humans Sex Distribution Methacholine Chloride Lung function Probability Air Pollutants Analysis of Variance business.industry Incidence Respiratory disease Airway inflammation respiratory system medicine.disease Respiratory Function Tests respiratory tract diseases Cross-Sectional Studies Italy Bronchial hyperresponsiveness Epidemiological Monitoring Immunology Female Methacholine Bronchial Hyperreactivity business Environmental Monitoring Follow-Up Studies medicine.drug |
| Zdroj: | Respiration. 71:51-59 |
| ISSN: | 1423-0356 0025-7931 |
| DOI: | 10.1159/000075649 |
| Popis: | Background: Outdoor air pollution is hazardous to human pulmonary health. Airway inflammation is an important cause of bronchial hyperresponsiveness. Information is not univocal about the potential effects of prolonged exposure to environmental air pollutants on lung function. Objectives: A cross-sectional study was performed to assess bronchial responsiveness to methacholine in children living in an air-polluted area. Afterwards, the same study protocol was repeated in children of similar age living in mountain valleys with virtually no air pollution. Methods: Every child underwent a lung function test, skin tests to common allergens, total serum levels of IgE, and a challenge to methacholine at increasing doses (PD20 FEV1). Subjects were 246 children 11–12 years old living in an air-polluted area, and 285 children 11–13 years old living in mountain valleys. Respectively, 156 and 161 were negative to skin tests and had serum total IgE Results: Lung function data, adjusted for the effect of potential confounders showed significantly lower FVC, and even more so FEV1, in the children from the polluted area. After the exclusion of subjects with positive skin tests and serum total IgE >100 IU/ml and those with history of asthma or respiratory disorders, there were higher percentages of positive responses in the challenge to methacholine in children from the polluted area (28.9 vs. 15.5%, p < 0.001). Conclusions: These data may corroborate the possible importance of long exposure to air pollutants on the prevalence of bronchial aspecific hyperresponsiveness in otherwise normal children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|