Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
| Autor: | T Monauni, Giovanni Targher, F. Saggiani, Michele Muggeo, Riccardo C. Bonadonna, M. Zenere, Maria Alberiche, Enzo Bonora |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Glucose clamp technique Carbohydrate metabolism medicine.disease Clamp Endocrinology In vivo Internal medicine Diabetes mellitus Internal Medicine medicine business Hyperinsulinism Homeostasis |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.23.1.57 |
| Popis: | OBJECTIVE: To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans. RESEARCH DESIGN AND METHODS: In the present study, we compared insulin sensitivity as assessed by a 4-h euglycemic (approximately 5 mmol/l) hyperinsulinemic (approximately 300 pmol/l) clamp with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity. RESULTS: We found a strong correlation between clamp-measured total glucose disposal and HOMA-estimated insulin sensitivity (r = -0.820, P |
| Databáze: | OpenAIRE |
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