Membrane raft domains and remodeling in aging brain
| Autor: | Thomas Claudepierre, Thierry Oster, Catherine Corbier, Julie Colin, Marie-Claire Lanhers, Catherine Malaplate-Armand, Frances T. Yen, Lynn Gregory-Pauron |
|---|---|
| Přispěvatelé: | Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA), Centre Hospitalier Universitaire (CHU), Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL) |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging Docosahexaenoic Acids [SDV]Life Sciences [q-bio] Biology Models Biological Biochemistry acide gras polyinsaturé n 3 Membrane Lipids 03 medical and health sciences Membrane Microdomains 0302 clinical medicine Alzheimer Disease Humans Aging brain Cognitive decline Lipid raft Lipid microdomain acide docosahexaénoique Brain Membrane Proteins Membrane raft Biological membrane vieillissement General Medicine membrane neuronale Cell biology Docosahexaenoic acid Neuroprotective Agents 030104 developmental biology Membrane Membrane protein ageing lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery |
| Zdroj: | Biochimie Biochimie, Elsevier, 2016, 130, pp.178-187. ⟨10.1016/j.biochi.2016.08.014⟩ |
| ISSN: | 0300-9084 |
| DOI: | 10.1016/j.biochi.2016.08.014 |
| Popis: | Lipids are the fundamental structural components of biological membranes. For a long time considered as simple barriers segregating aqueous compartments, membranes are now viewed as dynamic interfaces providing a molecular environment favorable to the activity of membrane-associated proteins. Interestingly, variations in membrane lipid composition, whether quantitative or qualitative, play a crucial role in regulation of membrane protein functionalities. Indeed, a variety of alterations in brain lipid composition have been associated with the processes of normal and pathological aging. Although not establishing a direct cause-and-effect relationship between these complex modifications in cerebral membranes and the process of cognitive decline, evidence shows that alterations in membrane lipid composition affect important physicochemical properties notably impacting the lateral organization of membranes, and thus microdomains. It has been suggested that preservation of microdomain functionality may represent an effective strategy for preventing or decelerating neuronal dysfunction and cerebral vulnerability, processes that are both aggravated by aging. The working hypothesis developed in this review proposes that preservation of membrane organization, for example, through nutritional supplementation of docosahexaenoic acid, could prevent disturbances in and preserve effective cerebral function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect