Targeting Head and Neck Cancer by Vaccination

Autor: Catherine Pointer, Gareth J. Thomas, Ruhcha V. Sutavani, James Dickie, Natalia Savelyeva, Chuan Wang
Rok vydání: 2018
Předmět:
lcsh:Immunologic diseases. Allergy
0301 basic medicine
Larynx
Oncology
medicine.medical_specialty
cancer antigens
Immunology
Review
Mice
Tobacco Use
03 medical and health sciences
Clinical Trials
Phase II as Topic
0302 clinical medicine
Antigens
Neoplasm
Risk Factors
Internal medicine
Tumor Microenvironment
medicine
Animals
Humans
Immunology and Allergy
Human papillomavirus
human papillomavirus
Antigens
Viral
Tumor microenvironment
Clinical Trials
Phase I as Topic
business.industry
Papillomavirus Infections
Smoking
Head and neck cancer
Pharynx
Cancer
human papillomavirus independent
medicine.disease
3. Good health
Vaccination
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
Smokeless tobacco
Head and Neck Neoplasms
030220 oncology & carcinogenesis
head and neck cancer
lcsh:RC581-607
business
cancer vaccines
Zdroj: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.00830
Popis: Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC. Novel therapeutic approaches for HNC will focus not only on effective vaccine platforms but will also target the stroma-rich immunosuppressive microenvironment found in those tumours.
Databáze: OpenAIRE
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