Principal component, Varimax rotation and cost analysis of volume effects in rectal bleeding in patients treated with 3D-CRT for prostate cancer
| Autor: | Michael J. Zelefsky, J. D. Bauer, Mark W. Skwarchuk, Andrew Jackson |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Varimax rotation medicine.medical_treatment Risk Assessment Correlation Prostate cancer Risk Factors medicine Humans Radiology Nuclear Medicine and imaging Radiation Injuries Radiation treatment planning Interpretability Principal Component Analysis Radiological and Ultrasound Technology business.industry Radiotherapy Planning Computer-Assisted Rectum Prostatic Neoplasms medicine.disease Surgery Radiation therapy Principal component analysis Radiology Radiotherapy Conformal Gastrointestinal Hemorrhage business Volume (compression) |
| Zdroj: | Physics in Medicine and Biology. 51:5105-5123 |
| ISSN: | 1361-6560 0031-9155 |
| DOI: | 10.1088/0031-9155/51/20/003 |
| Popis: | We investigate the utility of principal component analysis as a tool for obtaining dose-volume combinations related to rectal bleeding after radiotherapy for prostate cancer. A direct implementation of principal component analysis reduces the number of degrees of freedom from the patient's dose-volume histograms that are associated with bleeding. However, when low-variance principal components are strongly correlated to outcome, their interpretation is problematic. A Varimax rotation is employed to aid in interpretability of the low-variance principal components. This procedure brings us closer to finding unique dose-volume combinations related to outcome but reintroduces correlation, requiring analysis of the overlap of information contained in such modes. Finally, we present examples of cost-benefit analyses for candidate dose-volume constraints for use in treatment planning. |
| Databáze: | OpenAIRE |
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