Low grade urothelial carcinoma mimicking basal cell hyperplasia and transitional metaplasia in needle prostate biopsy
| Autor: | Raúl J. Ortiz-Bautista, Braulio Martínez-Benítez, Leticia Bornstein-Quevedo, Julián Arista-Nasr, Elizmara Aguilar-Ayala, Claudia Natalia Aleman-Sanchez |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Prostate biopsy Urology Prostatic Hyperplasia lcsh:RC870-923 Basal Cell Hyperplasia Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Prostate Metaplasia Biopsy Carcinoma medicine Humans Aged Carcinoma Transitional Cell Hyperplasia medicine.diagnostic_test business.industry Biopsy Needle Prostatic Neoplasms Middle Aged Prostate-Specific Antigen lcsh:Diseases of the genitourinary system. Urology medicine.disease Desmoplasia Prostate-specific antigen 030104 developmental biology medicine.anatomical_structure Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Original Article Neoplasm Grading Urothelium medicine.symptom Transitional Cell business |
| Zdroj: | International braz j urol v.42 n.2 2016 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International Brazilian Journal of Urology, Vol 42, Iss 2, Pp 247-252 (2016) International braz j urol, Volume: 42, Issue: 2, Pages: 247-252, Published: APR 2016 |
| Popis: | Purpose The vast majority of urothelial carcinomas infiltrating the bladder are consistent with high-grade tumors that can be easily recognized as malignant in needle prostatic biopsies. In contrast, the histological changes of low-grade urothelial carcinomas in this kind of biopsy have not been studied. Materials and Methods We describe the clinicopathologic features of two patients with low-grade bladder carcinomas infiltrating the prostate. They reported dysuria and hematuria. Both had a slight elevation of the prostate specific antigen and induration of the prostatic lobes. Needle biopsies were performed. At endoscopy bladder tumors were found in both cases. Results Both biopsies showed nests of basophilic cells and cells with perinuclear clearing and slight atypia infiltrating acini and small prostatic ducts. The stroma exhibited extensive desmoplasia and chronic inflammation. The original diagnosis was basal cell hyperplasia and transitional metaplasia. The bladder tumors also showed low-grade urothelial carcinoma. In one case, the neoplasm infiltrated the lamina propria, and in another, the muscle layer. In both, a transurethral resection was performed for obstructive urinary symptoms. The neoplasms were positive for high molecular weight keratin (34BetaE12) and thrombomodulin. No metastases were found in either of the patients, and one of them has survived for five years. Conclusions The diagnosis of low-grade urothelial carcinoma in prostate needle biopsies is difficult and may simulate benign prostate lesions including basal cell hyperplasia and urothelial metaplasia. It is crucial to recognize low-grade urothelial carcinoma in needle biopsies because only an early diagnosis and aggressive treatment can improve the prognosis for these patients. |
| Databáze: | OpenAIRE |
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