Two new steroids with cytotoxicity from the marine sponge Dactylospongia elegans collected from the South China Sea
| Autor: | Hou-Wen Lin, Zhuo Wang, Wei-Hua Jiao, Fan Yang, Jing Li, Shi-Hai Xu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Aquatic Organisms
Spectrometry Mass Electrospray Ionization Dactylospongia elegans Magnetic Resonance Spectroscopy South china Stereochemistry medicine.medical_treatment Antineoplastic Agents Plant Science Crystallography X-Ray 01 natural sciences Biochemistry Analytical Chemistry Steroid Ic50 values medicine Animals Humans Cytotoxicity Molecular Structure biology 010405 organic chemistry Chemistry Organic Chemistry biology.organism_classification Porifera 0104 chemical sciences 010404 medicinal & biomolecular chemistry Sponge MCF-7 Cells Steroids Drug Screening Assays Antitumor Cancer cell lines Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Natural Product Research. 33:1340-1344 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2018.1475385 |
| Popis: | A new steroid, (3S,5R,9R,10S,13R,17R,20R,24S,22E)-ergosta-6,8,22-triene-3,25-diol (1), and its sulfonated analogue (2) together with a known one, 5α,8α-epidioxy-cholest-6-en-3β-ol (3) were isolated from the marine sponge Dactylospongia elegans collected from the South China Sea. The new structures including absolute configurations were established by the HRESIMS and 1D and 2D NMR analysis coupled with the X-ray crystal analysis. Both of 1 and 2 exhibited cytotoxicity against cancer cell line MCF-7 with IC50 values of 9.7 and 8.5 μM, respectively. |
| Databáze: | OpenAIRE |
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