Non-surfactant nanospheres of progesterone inclusion complexes with amphiphilic beta-cyclodextrins
| Autor: | Dominique Duchêne, Amélie Bochot, A. Atilla Hincal, Erem Memişoğlu, Murat Şen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrins Chromatography Cyclodextrin beta-Cyclodextrins Pharmaceutical Science Fast atom bombardment Dosage form Microspheres Surface-Active Agents Differential scanning calorimetry Pulmonary surfactant chemistry Amphiphile Zeta potential Nanotechnology Alkyl Progesterone Nuclear chemistry |
| Zdroj: | International journal of pharmaceutics. 251(1-2) |
| ISSN: | 0378-5173 |
| Popis: | Amphiphilic b-cyclodextrins were formulated as nanospheres and characterised by particle size, zeta potential and TEM following freeze-fracture. The nanospheres were loaded with progesterone with different loading techniques involving the spontaneous formation of nanospheres from pre-formed inclusion complexes of amphiphilic bcyclodextrins modified on the primary or secondary face with progesterone. Inclusion complexes were characterised with various techniques including Differential Scanning Calorimetry (DSC), Fast Atom Bombardment Mass Spectrometry (FAB MS) and 1 H NMR spectroscopy; and progesterone was believed to be partially included in the CD cavity. Loading properties of conventionally-loaded nanospheres were compared with those prepared directly from pre-formed inclusion complexes and loading technique was found to enhance associated drug percentage significantly (P B/0.05). Although both amphiphilic b-cyclodextrins (6-N -CAPRO-b-CD and b-CDC6) were capable of high progesterone loading, b-CDC6 displayed slightly higher entrapment efficiency due to the possible higher affinity of progesterone to the 14 alkyl chains surrounding this molecule resulting in higher drug adsorption to particle surface. Progesterone was released within a period of 1 h from all formulations. Progesterone-loaded amphiphilic b-CD nanospheres were proved to be a promising non-surfactant injectable delivery system providing high-quantity of waterinsoluble progesterone rapidly within 1 h. # 2002 Elsevier Science B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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