Aminomethylation of Aryl Halides Using α-Silylamines Enabled by Ni/Photoredox Dual Catalysis

Autor:	Gary A. Molander, Camille Remeur, Niki R. Patel, Christopher B. Kelly
Rok vydání:	2017
Předmět:	010405 organic chemistry Chemistry Radical Aryl Halide General Chemistry 010402 general chemistry Photochemistry 01 natural sciences Combinatorial chemistry Article Catalysis 0104 chemical sciences Single electron chemistry.chemical_compound Amine gas treating
Zdroj:	ACS Catalysis. 7:6065-6069
ISSN:	2155-5435
DOI:	10.1021/acscatal.7b01973
Popis:	A protocol for the aminomethylation of aryl halides using α-silylamines via Ni/photoredox dual catalysis is described. The low oxidation potential of these silylated species enables facile single electron transfer (SET) oxidation of the amine followed by rapid desilylation. The resulting α-amino radicals can be directly funneled into a nickel-mediated cross-coupling cycle with aryl halides. The process accomplishes aminomethylation under remarkably mild conditions and tolerates numerous aryl- and heteroaryl halides with an array of functional groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2980ce4cbbbae84fbf2a3eb669ade5b https://doi.org/10.1021/acscatal.7b01973 Zobrazit plný text záznamu