Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway
| Autor: | Sina Mahdiani, Navid Omidkhoda, Shadi Heidari, A. Wallace Hayes, Gholamreza Karimi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | BioFactors. 48:744-762 |
| ISSN: | 1872-8081 0951-6433 |
| Popis: | Humans are continuously exposed to environmental, occupational, consumer and household products, food, and pharmaceutical substances. Luteolin, a flavone from the flavonoids family of compounds, is found in different fruits and vegetables. LUT is a strong anti-inflammatory (via inhibition of NF-κB, ERK1/2, MAPK, JNK, IL-6, IL-8, and TNF-α) and antioxidant agent (reducing ROS and enhancement of endogenous antioxidants). LUT can chelate transition metal ions responsible for ROS generation and consequently repress lipoxygenase. It has been proven that NF-κB, as a commom cellular pathway plays a considerable role in the progression of inflammatory process and stimulates the expression of genes encoding inducible pro-inflammatory enzymes (iNOS and COX-2) and cytokines including IL-1β, IL-6, and TNF-α. This review summarizes the available literature discussing LUT and its potential protective role against pharmaceuticals-, metals-, and environmental compounds-induced toxicities. Furthermore, the review explains the involved protective mechanisms, especially inhibition of the NF-κB pathway. |
| Databáze: | OpenAIRE |
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