Distinct profiles of antibodies to Kaposi sarcoma-associated herpesvirus antigens in patients with Kaposi sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma

Autor: Richard F. Little, Kathleen M. Wyvill, Kathryn H. Ching, Robert Yarchoan, Peter D. Burbelo, Joseph A. Kovacs, Alexandra T. Issa, Michael J. Iadarola
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Cancer Research
medicine.medical_specialty
Pathology
Epidemiology
Multicentric Castleman's disease
viruses
Lymphoproliferative disorders
Antibodies
Viral
Meeting Abstracts
Sensitivity and Specificity
lcsh:RC254-282
Article
lcsh:Infectious and parasitic diseases
Immune system
Antigen
Lymphoma
Primary Effusion
Virology
Kaposi sarcoma-associated herpesvirus
Immunology and Allergy
Medicine
Humans
In patient
Serologic Tests
lcsh:RC109-216
Kaposi's sarcoma
Antigens
Viral
Sarcoma
Kaposi
biology
business.industry
Castleman Disease
nutritional and metabolic diseases
virus diseases
biochemical phenomena
metabolism
and nutrition
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
eye diseases
Lymphoma
Infectious Diseases
Lytic cycle
Oncology
Tropical medicine
Herpesvirus 8
Human
biology.protein
Primary effusion lymphoma
Sarcoma
Antibody
business
Zdroj: Infectious Agents and Cancer, Vol 5, Iss Suppl 1, p A20 (2010)
Infectious Agents and Cancer
ISSN: 1750-9378
Popis: Kaposi sarcoma–associated herpes virus (KSHV), also called human herpesvirus-8 (HHV-8), is the causative agent of all forms of Kaposi sarcoma (KS) [1, 2]. In KS, most proliferating tumor spindle cells are infected with KSHV and express KSHV proteins [1, 2]. KSHV has a 170.5 kb genome encoding approximately 90 gene products and contains a number of pirated genes involved in cell proliferation, angiogenesis, and evasion of the immune system [3]. KSHV is also the causative agent of two rare B-cell lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD), that occur primarily in patients infected with human immunodeficiency virus (HIV). PEL is characterized by its tendency to develop in body cavities such as pleural or peritoneal spaces [4-6]. MCD is characterized clinically by fevers, wasting, hypoalbuminemia, and cytopenias that result from overproduction of viral-encoded and human-encoded cytokines, especially interleukin-6 (IL-6) [7, 8]. Like other herpesviruses, KSHV has two phases of gene expression, latent and lytic. In KS, a majority of KSHV-infected spindle cells express only latent genes, while a small percentage express lytic genes [9-11]. By contrast, a substantial percentage of MCD cells express lytic KSHV genes, including a virally-encoded IL-6. The majority of PEL cells express KSHV latent genes, but in addition can show limited expression of certain lytic genes [9-11]. Luciferase immunoprecipitation systems (LIPS) is a powerful new method to quantitatively measure antibody responses to a wide range of infectious agents. LIPS screening of a panel of KSHV antigens identified v-cyclin as a useful diagnostic antigen that along with 3 other antigens, provided high sensitivity and specificity for the differentiation between patients with KS and blood bank donor controls [12]. Given the differential expression of KSHV lytic and latent proteins in KS, PEL, and MCD, we hypothesized that different antibody profiles to KSHV antigens detected by LIPS might distinguish these diseases.
Databáze: OpenAIRE
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