Does fasting during Ramadan influence the therapeutic effect of warfarin?
| Autor: | Aysha Husain, Ali Mohamed Qader, Kannan Sridharan, Rashed Al Banna |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty WARFARIN SENSITIVITY Nice 030226 pharmacology & pharmacy 03 medical and health sciences Young Adult 0302 clinical medicine Therapeutic index medicine Humans Pharmacology (medical) 030212 general & internal medicine International Normalized Ratio Blood Coagulation computer.programming_language Aged Retrospective Studies Pharmacology Aged 80 and over business.industry Therapeutic effect Warfarin Anticoagulants Fasting Middle Aged Religion Increased risk Concomitant Pharmacodynamics Female business computer medicine.drug |
| Zdroj: | Journal of clinical pharmacy and therapeuticsREFERENCES. 46(1) |
| ISSN: | 1365-2710 |
| Popis: | WHAT IS KNOWN AND OBJECTIVES The changes in the therapeutic effect of warfarin during Ramadan fasting are controversial. Hence, we carried out the present study to assess if there are any alterations in the anticoagulation response to warfarin and identify the associated risk factors. METHODS Patients receiving warfarin for at least 1 year were included in the present study. Their demographic details, warfarin doses, prothrombin time-international normalized ratio (PT-INR) values and concomitant diseases/drugs were retrieved. The dates of Ramadan periods for the calendar years were obtained, and these periods were considered as Ramadan periods. One month before the start dates of Ramadan was considered as pre-Ramadan, and 1 month later than the last dates was considered as post-Ramadan periods. Warfarin sensitivity index (WSI), PT-INR category and time spent in therapeutic range (TTR) were assessed. National Institute of Clinical Health Excellence (NICE) criteria for anticoagulation status were adhered to where TTR (%) |
| Databáze: | OpenAIRE |
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