Real-life effectiveness of biological therapies on symptoms in severe asthma with comorbid CRSwNP
| Autor: | C Mümmler, K Dünzelmann, N Kneidinger, M Barnikel, D Munker, M Gröger, M Canis, J Behr, A Koch, F Haubner, K Milger |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Clin. Transl. Allergy 11:e12049 (2021) Clinical and Translational Allergy |
| Popis: | BACKGROUND: We aimed to evaluate the effectiveness of different antibody therapies on nasal polyp symptoms in patients treated for severe asthma. METHODS: We performed a retrospective analysis of patients with severe asthmaand comorbid CRSwNP who were treated with anti-IgE, anti-IL-5/R or anti-IL-4R. CRSwNP symptom burden was evaluated before and after 6months of therapy. RESULTS: Fifty patients were included hereof treated with anti-IgE: 9, anti-IL-5/R: 26 and anti-IL-4R: 15 patients. At baseline median SNOT-20 was similar among groups (anti-IgE: 55, anti-IL-5/R: 52 and anti-IL-4R: 56, p=0.76), median visual analogue scale (VAS) for nasal symptoms was 4, 7 and 8 (p=0.14) and VAS for total symptoms was higher in the anti-IL-4R group (4, 5 and 8, p=0.002). After 6months SNOT-20 improved significantly in all patient groups with median improvement of anti-IgE: -8 (p |
| Databáze: | OpenAIRE |
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