Biotin deficiency and biotin excess: effects on the female reproductive system
| Autor: | Teresa Neri-Gómez, Roberto Chavira, Alberto Rojas-Ochoa, Jesús Javier Espinosa-Aguirre, Georgina Díaz, Cristina Fernandez-Mejia, Paz Vital, Armida Báez-Saldaña, Elena Larrieta, Christian Guerra-Araiza, Ignacio Camacho-Arroyo |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Clinical Biochemistry Biotin deficiency Biotin Ovary Estrous Cycle Receptors Estradiol Biology Biochemistry chemistry.chemical_compound Mice Endocrinology Internal medicine medicine Animals RNA Messenger Molecular Biology Progesterone Pharmacology Estrous cycle Mice Inbred BALB C Estradiol Reproduction Organic Chemistry Body Weight Uterus Sex hormone receptor Organ Size medicine.disease Diet B vitamins medicine.anatomical_structure chemistry Liver Estrogen Hormone receptor Female Receptors Progesterone |
| Zdroj: | Steroids. 74(10-11) |
| ISSN: | 1878-5867 |
| Popis: | Biotin deficiency and biotin excess have both been found to affect reproduction and cause teratogenic effects. In the reproductive tract, however, the effects of biotin have not been well established yet. We investigated the effects of varying biotin content diets on the oestrus cycle, ovarian morphology, estradiol and progesterone serum levels, and the uterine mRNA abundance of their nuclear receptors, as well as on the activity of the estradiol-degrading group of enzymes cytochrome P450 (CYP) in the liver. Three-week-old female BALB/cAnN Hsd mice were fed a biotin-deficient, a biotin-control, or a biotin-supplemented diet (0, 7.2 or 400 micromol of free biotin/kg diet, respectively) over a period of nine weeks. Striking effects were observed in the biotin-deficient group: mice showed arrested estrous cycle on the day of diestrus and changes in ovary morphology. Estradiol serum concentration increased 49.2% in biotin-deficient mice compared to the control group, while the enzymatic activities of CYP1A2 and CYP2B2 increased (P |
| Databáze: | OpenAIRE |
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