Amino Acid and Phospholipid Metabolism as an Indicator of Inflammation and Subtle Cardiomyopathy in Patients with Marfan Syndrome
| Autor: | Thomas Karall, Gregor Oemer, Lisa Bartenbach, Miriam Michel, Herbert Oberacher, Sabine Scholl-Bürgi, Markus A. Keller, Ralf Geiger, Irena Odri-Komazec, Safwat Aly, Jakob Koch, Katharina Meinel, Daniela Karall, Daniela Baumgartner |
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| Rok vydání: | 2021 |
| Předmět: |
Marfan syndrome
medicine.medical_specialty Taurine Endocrinology Diabetes and Metabolism Diastole Cardiomyopathy medicine.disease_cause Microbiology Biochemistry Article Aortic aneurysm chemistry.chemical_compound Internal medicine Medicine cardiovascular diseases Molecular Biology business.industry medicine.disease metabolomics QR1-502 cardiomyopathy taurine Pathophysiology Endocrinology chemistry Biomarker (medicine) business Oxidative stress |
| Zdroj: | Metabolites Metabolites; Volume 11; Issue 12; Pages: 805 Metabolites, Vol 11, Iss 805, p 805 (2021) |
| ISSN: | 2218-1989 |
| Popis: | Patients with Marfan syndrome (MFS) have an increased risk of aortic aneurysm formation, dissection and development of a subtle cardiomyopathy. We analyzed amino acid and lipid metabolic pathways in MFS patients, seeking biomarker patterns as potential monitoring tools of cardiovascular risk with deterioration of myocardial function. We assessed myocardial function in 24 adult MFS patients and compared traditional laboratory values and mass spectrometry-based amino acid, phospholipid and acylcarnitine metabolomes in patients with those in healthy controls. Analytes for which values differed between patients and controls were subjected to regression analysis. A high proportion of patients had signs of impaired diastolic function and elevated serum levels of NT-proBNP. Patients had lower serum levels of taurine, histidine and PCaeC42:3 than controls. The evidence of diastolic dysfunction, aortic root dimensions and history of aortic root surgery correlated with NT-proBNP and taurine levels. Alterations in serum levels of metabolism derived analytes link MFS pathophysiology with inflammation, oxidative stress and incipient cardiomyopathy. |
| Databáze: | OpenAIRE |
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