Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity

Autor:	Natalie Dulaney, Kathleen M. Antony, Saverio Capuano, Cristhian Salas-Quinchucua, Mason Bliss, Andres Mejia, Sabrina A. Kabakov, Thomas C. Friedrich, Chelsea M. Crooks, Matthew T. Aliota, Jens C. Eickhoff, Heather A. Simmons, David H. O’Connor, Thaddeus G. Golos, Ann Mitzey, Logan T Keding, Lex G. Medina-Magües, Andrea M. Weiler, Mary L. Schneider, Emma L. Mohr, Kathryn M. Bach, Elaina Razo, Karla Ausderau, Terry K. Morgan
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Offspring viruses prenatal ZIKV exposure Dengue virus Motor Activity medicine.disease_cause Antibodies Viral Microbiology Macaque Nervous System Virus Article Dengue fever Zika virus Dengue Fetal Development Immunity Pregnancy Virology biology.animal Orientation Medicine Animals Pregnancy Complications Infectious biology neurodevelopment business.industry Zika Virus Infection virus diseases Zika Virus biochemical phenomena metabolism and nutrition Dengue Virus medicine.disease biology.organism_classification Macaca mulatta QR1-502 maternal DENV infection macaque model Disease Models Animal Infectious Diseases Animals Newborn Prenatal Exposure Delayed Effects Immunology Female business
Zdroj:	Viruses Volume 13 Issue 9 Viruses, Vol 13, Iss 1878, p 1878 (2021)
ISSN:	1999-4915
Popis:	Infants exposed to Zika virus (ZIKV) prenatally may develop birth defects, developmental deficits, or remain asymptomatic. It is unclear why some infants are more affected than others, although enhancement of maternal ZIKV infection via immunity to an antigenically similar virus, dengue virus (DENV), may play a role. We hypothesized that DENV immunity may worsen prenatal ZIKV infection and developmental deficits in offspring. We utilized a translational macaque model to examine how maternal DENV immunity influences ZIKV-exposed infant macaque neurodevelopment in the first month of life. We inoculated eight macaques with prior DENV infection with ZIKV, five macaques with ZIKV, and four macaques with saline. DENV/ZIKV-exposed infants had significantly worse visual orientation skills than ZIKV-exposed infants whose mothers were DENV-naive, with no differences in motor, sensory or state control development. ZIKV infection characteristics and pregnancy outcomes did not individually differ between dams with and without DENV immunity, but when multiple factors were combined in a multivariate model, maternal DENV immunity combined with ZIKV infection characteristics and pregnancy parameters predicted select developmental outcomes. We demonstrate that maternal DENV immunity exacerbates visual orientation and tracking deficits in ZIKV-exposed infant macaques, suggesting that human studies should evaluate how maternal DENV immunity impacts long-term neurodevelopment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25209b3b06036aa044b1a530c597d92 http://europepmc.org/articles/PMC8473338 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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