Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents
| Autor: | Thierry Roisnel, Sofiane Bouacida, Ali Belfaitah, Chafia Bentchouala, Farida Smati, Bertrand Carboni, Abdelmalek Bouraiou, Saida Benzerka |
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| Přispěvatelé: | Laboratoire des produits naturels d'origine végétal et de synthèse organique (PHYSYNOR), Université Mentouri Constantine [Algérie] (UMC), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université frères Mentouri Constantine I (UMC), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
heterocycles
crystal structure antimicrobial activity 010405 organic chemistry Pseudomonas aeruginosa Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry Biological activity minimum inhibitory concentration 010402 general chemistry medicine.disease_cause medicine.disease Antimicrobial 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Minimum inhibitory concentration Staphylococcus aureus 2-Phenylquinoline medicine Klebsiella pneumonia Antibacterial activity Escherichia coli |
| Zdroj: | Letters in Organic Chemistry Letters in Organic Chemistry, Bentham Science Publishers, 2013, 10 (2), pp.94-99. ⟨10.2174/1570178611310020005⟩ Letters in Organic Chemistry, 2013, 10 (2), pp.94-99. ⟨10.2174/1570178611310020005⟩ |
| ISSN: | 1570-1786 |
| Popis: | International audience; Some new unfused tricyclic aromatic systems containing various heterocyclic cores were synthesized. These compounds were prepared in good yields via appropriate routes using 6-methyl-2-phenylquinoline-3-carbaldehyde as a key intermediate. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Salmonella thipymurium using the disk-diffusion method. The minimum inhibitory concentration (MIC) was determined for the tested compounds. |
| Databáze: | OpenAIRE |
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