von Willebrand factor propeptide‐to‐antigen ratio in HIV‐infected pregnancy: Evidence of endothelial activation
| Autor: | Harry R. Büller, Elise Schapkaitz, Elena Libhaber, Barry F. Jacobson, Muriel Meiring |
|---|---|
| Přispěvatelé: | Vascular Medicine, ACS - Pulmonary hypertension & thrombosis |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
antiretroviral therapy ADAMTS13 Protein endothelial activation HIV Infections Endothelial activation Von Willebrand factor Antigen Pregnancy Internal medicine von Willebrand Factor medicine Humans ADAMTS-13 Antigens Pregnancy Complications Infectious Thrombospondin Metalloproteinase von Willebrand factor propeptide human immunodeficiency virus biology business.industry Venous Thromboembolism Hematology medicine.disease ADAMTS13 Endocrinology biology.protein Female business Viral load von Willebrand factor antigen |
| Zdroj: | Journal of thrombosis and haemostasis, 19(12), 3168-3176. Wiley-Blackwell |
| ISSN: | 1538-7836 1538-7933 |
| DOI: | 10.1111/jth.15502 |
| Popis: | Background: Endothelial activation has been proposed as a potential mechanism for the increased risk of venous thromboembolism (VTE) in human immunodeficiency virus (HIV)–infected pregnancy. Objectives: To assess the state of endothelial activation in HIV-infected pregnancy by measuring the von Willebrand factor (VWF) propeptide-to-antigen ratio, as an index of acute endothelial activation. Methods: VWF antigen and VWF propeptide were measured in HIV-negative participants (n = 85), HIV-infected virologically suppressed participants, (n = 89) and HIV-infected participants with HIV viral load (VL) of >50 copies/ml (n = 63) in each trimester. Results were correlated with multimer patterns and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13) antigen, activity, and antibody levels. Results: VWF propeptide-to-antigen ratio was increased, in the first, second, and third trimester, in the HIV-infected virologically suppressed group (1.7 ± 0.7, 1.7 ± 0.4, 1.6 ± 0.5) and the HIV-infected group with VL > 50 copies/ml (1.9 ± 0.9, 1.7 ± 0.9, 1.6 ± 1.1) compared to the HIV-negative group (1.4 ± 0.6, 1.3 ± 0.4, 1.2 ± 0.3, P |
| Databáze: | OpenAIRE |
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