Editorial Commentary: Third-Generation Autologous Chondrocyte Implantation-Are Cells Seeded Onto the Scaffold Itself in It for the Long Run?
| Autor: | Christopher L. McCrum |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cartilage
Articular 030222 orthopedics Scaffold business.industry Cartilage education Collagen membrane 030229 sport sciences Magnetic Resonance Imaging Transplantation Autologous Third generation Transplantation 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Chondrocytes Medicine Humans Orthopedics and Sports Medicine Patient Reported Outcome Measures business Autologous chondrocyte implantation Biomedical engineering |
| Zdroj: | Arthroscopy : the journal of arthroscopicrelated surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 36(7) |
| ISSN: | 1526-3231 |
| Popis: | Autologous chondrocyte implantation (ACI) is an increasingly performed procedure, with rapidly evolving technology. First-generation ACI used a periosteal patch, leading to the second generation, in which a type I-type III collagen membrane is used to cover the autologous chondrocytes, and ultimately the third generation, in which autologous chondrocytes are seeded onto the scaffold itself. As third-generation, scaffold-based ACI techniques are becoming more widely available, interest in the long-term clinical and radiographic outcomes continues to grow, especially given the high costs associated with these procedures. Several studies have now shown persistently improved clinical outcomes at long-term follow-up, which support the increasing utilization of third-generation ACI techniques. However, it is important to continue to develop our understanding of the limitations of and expectations with third-generation ACI, particularly regarding reoperation, as well as to continue to design high-quality long-term studies that can evaluate differences in technology. |
| Databáze: | OpenAIRE |
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