Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A
| Autor: | Kazuyoshi Kawahara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Long lasting International Cooperation Immunology Chemistry Organic Microbiology Chemical synthesis History 21st Century Lipid A 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Molecular level Japan Escherichia coli lipid IVa Molecular Biology Natural product Re LPS Cell Biology Original Articles History 20th Century Shock Septic humanities 030104 developmental biology Infectious Diseases chemistry Biochemistry Three generations lcsh:RC581-607 030215 immunology |
| Zdroj: | Innate Immunity Innate Immunity, Vol 25 (2019) |
| ISSN: | 1753-4267 1753-4259 |
| Popis: | Endotoxin research in recent years at the molecular level has required chemically synthesized lipid A without contamination by other bioactive components. Total synthesis of Escherichia coli-type lipid A was achieved in the 1980s by the challenging spirits of the scientists at Osaka University, Japan. They clarified the role of lipid A in the immunological activities of endotoxin in collaboration with Japanese and German researchers, based on the friendships that existed between them. This article introduces the great contributions made by three generations of professors, Tetsuo Shiba, Shoichi Kusumoto, and Koichi Fukase, at the Laboratory of Natural Product Chemistry at Osaka University, to the study over four decades of endotoxin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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