Self-collected versus clinician-collected samples for HSV-2 and HSV-2/HPV screening in HIV-infected and -uninfected women in the Tapajós region, Amazon, Brazil
| Autor: | Lyana Rodrigues Pinto Lima, Mariza G. Morgado, Vanessa Salete de Paula, Charlotte A. Gaydos, Alcina F. Nicol, Katrini Guidolini Martinelli, Luana Lorena Silva Rodrigues, José Henrique Pilotto, Justin Hardick |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Herpesvirus 2 Human viruses 030231 tropical medicine Human immunodeficiency virus (HIV) HIV Infections Dermatology HSL and HSV medicine.disease_cause Polymerase Chain Reaction Specimen Handling 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Hiv infected Epidemiology medicine Humans Mass Screening Pharmacology (medical) 030212 general & internal medicine Human papillomavirus Papillomaviridae Coinfection business.industry Amazon rainforest Papillomavirus Infections Public Health Environmental and Occupational Health Reproducibility of Results Hpv screening Virology Self Care Cross-Sectional Studies Infectious Diseases Herpes simplex virus Case-Control Studies DNA Viral business Brazil |
| Zdroj: | International Journal of STD & AIDS. 30:1055-1062 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1177/0956462419842007 |
| Popis: | The aim of this study was to evaluate the prevalence of herpes simplex virus 2 (HSV-2) and HSV-2/human papillomavirus (HPV) co-infection by self-collected samples compared to clinician-collected samples in human immunodeficiency virus 1 (HIV-1)-infected and -uninfected women from the Tapajós region, Amazon, Brazil. A cross-sectional study was conducted with 439 anal and cervical scrapings and cervico-vaginal self-collected samples obtained from 153 eligible HIV-infected and -uninfected women. Real-time PCR for HSV-2 and nested PCR for HPV detection were performed. A multivariate analysis identified risk factors for HSV-2/HPV co-infection. The anogenital prevalence of HSV-2 was 9.2% (14/153), HPV was 67.3% (103/153) and HSV-2/HPV co-infection was 6.5% (10/153). There was a significant overall agreement (95.5%, 11/133, kappa 0.64, 95% CI 0.38–0.90, p |
| Databáze: | OpenAIRE |
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