Melatonin induces changes to serum cytokines in mice infected with the Venezuelan equine encephalomyelitis virus
| Autor: | Jorge García Tamayo, Luz Marina Espina, Ernesto Bonilla, Leonor Chacín-Bonilla, Nereida Valero, Shirley Medina-Leendertz, Héctor Pons, Florencio Añez |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Interferon type II Encephalomyelitis medicine.medical_treatment Biology medicine.disease_cause Melatonin Interferon-gamma Mice Th2 Cells Adjuvants Immunologic Aldesleukin Internal medicine medicine Animals Interferon gamma Tumor Necrosis Factor-alpha Interleukins Public Health Environmental and Occupational Health Interleukin Encephalomyelitis Venezuelan Equine General Medicine Th1 Cells medicine.disease Infectious Diseases Endocrinology Cytokine Immunology Venezuelan equine encephalitis virus Cytokines Parasitology medicine.drug |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 96:348-351 |
| ISSN: | 0035-9203 |
| Popis: | We determined the influence of melatonin (MLT) on the induction of interleukin (IL)-2, IL-1 beta, IL-4, tumour necrosis factor-alpha (TNF-alpha) and gamma interferon (IFN-gamma) on mice infected with the Venezuelan equine encephalomyelitis (VEE) virus. Levels of IFN-gamma in the MLT-treated group were significantly increased (P < 0.001) when compared with the control non-infected group from day 1 to 6 post-infection (p.i.), while in infected mice treated with 500 micrograms MLT/kg of bodyweight enhanced levels of IFN-gamma were evident from 4 to 6 days p.i. No differences were detected in the levels of IL-2 between the controls, the infected mice treated with MLT and the infected untreated group, from day 2 p.i. No changes in serum levels of IL-4 were detected. In infected mice treated with MLT, blood levels of IL-1 beta were elevated almost 10-fold from day 1 to day 6 p.i. when compared to the control, the infected and the non-infected MLT-treated mice (P < 0.001). A highly significant rise (P < 0.001) of TNF-alpha was found in infected mice treated with MLT, from day 1 to 6 p.i. when compared to the other groups. A significant rise (P < 0.001) was also evident in the infected non-MLT-treated group and a less pronounced rise in the non-infected mice treated with MLT when compared to controls. The blockade of IFN-gamma and TNF-alpha did not inhibit the protective effect of MLT but when IL-1 beta was neutralized, 100% of the infected mice died suggesting that IL-1 beta induced by MLT treatment is a target cytokine to generate an immune response against the viral infection. |
| Databáze: | OpenAIRE |
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