Dynamic contrast-enhanced MRI quantification of synovium microcirculation in experimental arthritis
| Autor: | Wendy Oakden, Andrea S. Doria, Marianne Rogers, Rahim Moineddin, Kenneth P.H. Pritzker, Michael D. Noseworthy, Roland Jong, Tammy Rayner, Vivian Tassos, Doreen Engelberts, Paul Babyn |
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| Rok vydání: | 2006 |
| Předmět: |
Experimental arthritis
Male Musculoskeletal imaging Pathology medicine.medical_specialty business.industry Arthritis Microcirculation Pediatric imaging Synovial Membrane Contrast Media Vascular permeability General Medicine medicine.disease Magnetic Resonance Imaging Increased capillary permeability Dynamic contrast-enhanced MRI Medicine Animals Radiology Nuclear Medicine and imaging Rabbits business |
| Zdroj: | AJR. American journal of roentgenology. 186(4) |
| ISSN: | 0361-803X |
| Popis: | Our objective was to analyze MRI contrast-enhancement patterns in arthritic and nonarthritic knees and the relationship of those patterns with clinical, laboratory, and histologic synovium markers.Dynamic contrast-enhanced MRI was performed in nine arthritic and three nonarthritic knees of juvenile rabbits. A two-compartment pharmacokinetic model of signal intensity-time data was implemented to generate parametric maps of signal slope, maximal percentage of signal change, capillary permeability, leakage space volume, and time-to-peak. MRI values were compared with clinical, laboratory, and histologic markers for evaluation of synovial changes during the progression of arthritis.Parametric maps of capillary permeability and signal slope depicted significant differences between arthritic and nonarthritic knees. Arthritic knees showed increased capillary permeability (p = 0.006) and signal slope (p = 0.01) with time after onset of disease as opposed to nonarthritic knees (permeability, p = 0.65; slope, p = 0.56). Significant correlations were found between temporal changes in capillary permeability (p = 0.002), signal slope (p = 0.003), and serum concentrations of amyloid A. No relationship was noted between any MRI parameters and histologic scores. The discriminative power of MRI indexes varied according to the stage of arthritis: time-to-peak was most accurate for differentiation of presence versus absence of arthritis in early arthritis (day 1, p = 0.0002), and signal slope was most accurate in midterm arthritis (day 14, p = 0.001).In vivo capillary permeability and signal slope have distinctive dynamic MRI properties. The accuracy of MRI parameters for diagnostic evaluation of experimental arthritis differs according to the stage of disease. |
| Databáze: | OpenAIRE |
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