Molecular size of retinal vascular leakage determined by FITC-dextran angiography in patients with posterior uveitis
| Autor: | Dudley C. Dumonde, S Jones, B A Ellis, E G Atkinson, Elizabeth M. Graham |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Eye disease Optic Disk Blood–retinal barrier Macular Degeneration chemistry.chemical_compound Ophthalmology Blood-Retinal Barrier medicine Humans Fluorescein Angiography medicine.diagnostic_test business.industry Retinal Vessels Dextrans Uveitis Posterior Retinal Uvea Fluorescein angiography medicine.disease Surgery Molecular Weight medicine.anatomical_structure Dextran chemistry Angiography Female business Fluorescein-5-isothiocyanate Uveitis |
| Zdroj: | Eye. 5:440-446 |
| ISSN: | 1476-5454 0950-222X |
| DOI: | 10.1038/eye.1991.71 |
| Popis: | In order to investigate the selective breakdown of the blood-retinal barrier in posterior uveitis angiograms were performed using fluorescein-conjugated dextrans (FITC-dextrans) of different molecular weights (150-kDa, 20-kDa, and 4-kDa) in two healthy controls and six patients with posterior uveitis, and the results compared with those of conventional fluorescein angiography. The smallest FITC-dextran could not penetrate the healthy blood-retinal barrier. Leakage of FITC-dextrans of all sizes was seen from swollen optic discs; dextrans of 4-kDa and 20-kDa leaked from areas of macula oedema; and retinal new vessels allowed the passage of 4-kDa molecules only. These results indicate that there is a differential breakdown of the blood-retinal barrier according to molecular size in various clinical situations associated with posterior uveitis. |
| Databáze: | OpenAIRE |
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