The Biological Function of Hepatitis B Virus X Protein in Hepatocellular Carcinoma
| Autor: | Zhihua Lin, Shaodong Zheng, Songgang Gu, Qiaodong Xu, Jiahong Liang, Jiang Yan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Hepatitis B virus Carcinoma Hepatocellular Angiogenesis viruses Apoptosis Review Virus Metastasis 03 medical and health sciences 0302 clinical medicine Cell Movement Carcinoma medicine Humans Hepatitis B virus (HBV) Carcinogenic mechanism Viral Regulatory and Accessory Proteins Hepatocellular carcinoma (HCC) Neoplasm Metastasis neoplasms Cell Proliferation Neovascularization Pathologic business.industry Cell growth Hepatitis B virus X (HBx) protein Liver Neoplasms General Medicine medicine.disease Hepatitis B digestive system diseases HBx 030104 developmental biology Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Trans-Activators business |
| Zdroj: | Oncology Research |
| ISSN: | 1555-3906 0965-0407 |
| Popis: | Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear. This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A detailed study of the biological functions of HBx will help to elucidate the mechanism of hepatocarcinogenesis and lead to the development of novel therapeutic targets for the treatment of HBV-related HCC. |
| Databáze: | OpenAIRE |
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