Evaluation of intestinal damage biomarkers in calves with atresia coli
| Autor: | Ugur Aydogdu, Erdem Gülersoy, Amir Naseri, Mahmut Ok, Kurtuluş Parlak, Ramazan Yildiz, Merve Ider |
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| Přispěvatelé: | Selçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü., Ok, Mahmut., Ider, Merve., Naseri, Amir., Gulersoy, Erdem., Veteriner Fakültesi |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
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medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities lfabp Veterinary medicine atresia coli Gastroenterology calves 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum Internal medicine SF600-1100 medicine otorhinolaryngologic diseases Dairy cattle General Veterinary business.industry Trefoil factor 3 030208 emergency & critical care medicine ifabp Pathophysiology Lactic acid medicine.anatomical_structure chemistry Blood chemistry Abdomen Alkaline phosphatase 030211 gastroenterology & hepatology business Research Article |
| Zdroj: | Journal of Veterinary Research, Vol 62, Iss 3, Pp 379-384 (2018) Journal of Veterinary Research |
| ISSN: | 2450-8608 3058-4620 |
| Popis: | WOS: 000448623500021 PubMed: 30584620 Introduction: Intestinal obstruction such as atresia coli causes pathophysiological changes in gastrointestinal tissue due to the rise of intra-abdominal pressure. The aim of this study is to determine the intestinal damage with intestinal biomarkers in calves with atresia coli. Material and Methods: The study was conducted on 40 Holstein calves diagnosed with atresia coli with mild to moderate abdominal distention and 10 healthy Holstein calves which served as the control. Blood samples were collected from all calves, and then serum concentrations of intestinal biomarkers were estimated, namely intestinal fatty acid binding protein (IFABP), liver fatty acid binding protein (LFABP), trefoil factor 3 (TFF3), and intestinal alkaline phosphatase (IAP), using commercially available specific bovine ELISA kits. An automatic blood gas analyser was employed for determining the lactate concentration. Results: The concentrations of serum LFABP (P < 0.01), IFABP, TFF3, IAP, and blood lactate (P < 0.001) were significantly higher in calves with atresia coli than in healthy calves. Conclusion: The calves affected with atresia coli exhibited severe intestinal damage, and IFABP, LFABP, and TFF3 have significant diagnostic importance and play a useful role in determining the intestinal damage due to intestinal obstruction. High levels of IAP and lactate may serve as a signal for the development of intestinal injury. Selcuk University, Scientific Research Project Office [15401147] This study was supported by a grant received from the Selcuk University, Scientific Research Project Office (Project number: 15401147). |
| Databáze: | OpenAIRE |
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