Influence of daily 10-85 mu g vitamin D supplements during pregnancy and lactation on maternal vitamin D status and mature milk antirachitic activity
| Autor: | Anne Schaafsma, Eline Stoutjesdijk, Jan C. van der Molen, D.A. Janneke Dijck-Brouwer, Ido P. Kema, Frits A. J. Muskiet |
|---|---|
| Přispěvatelé: | Lifestyle Medicine (LM), Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) INFANTS chemistry.chemical_compound 0302 clinical medicine Pregnancy Supplements Vitamin D Infant Nutritional Physiological Phenomena Cholecalciferol RISK Nutrition and Dietetics Postpartum Period WOMEN Prenatal Care Vitamins Breast Feeding Adequate intake Female HEALTH Vitamin Adult medicine.medical_specialty Breast milk BIRTH Nutritional Status 030209 endocrinology & metabolism Rickets METABOLISM vitamin D deficiency CALCIUM 03 medical and health sciences Internal medicine HUMAN BREAST-MILK medicine Vitamin D and neurology Humans Lactation COHORT 030109 nutrition & dietetics Milk Human business.industry Infant Newborn Infant Maternal Nutritional Physiological Phenomena medicine.disease 25-HYDROXYVITAMIN D LEVELS Endocrinology chemistry Antirachitic activity Dietary Supplements Calcifediol business Breast feeding Postpartum period |
| Zdroj: | British Journal of Nutrition, 121(4), 426-438. Cambridge University Press |
| ISSN: | 0007-1145 |
| Popis: | Pregnant and lactating women and breastfed infants are at risk of vitamin D deficiency. The supplemental vitamin D dose that optimises maternal vitamin D status and breast milk antirachitic activity (ARA) is unclear. Healthy pregnant women were randomised to 10 (n 10), 35 (n 11), 60 (n 11) and 85 (n 11) µg vitamin D3/d from 20 gestational weeks (GW) to 4 weeks postpartum (PP). The participants also received increasing dosages of fish oil supplements and a multivitamin. Treatment allocation was not blinded. Parent vitamin D and 25-hydroxyvitamin D (25(OH)D) were measured in maternal plasma at 20 GW, 36 GW and 4 weeks PP, and in milk at 4 weeks PP. Median 25(OH)D and parent vitamin D at 20 GW were 85 (range 25–131) nmol/l and ‘not detectable (nd)’ (range nd–40) nmol/l. Both increased, seemingly dose dependent, from 20 to 36 GW and decreased from 36 GW to 4 weeks PP. In all, 35 µg vitamin D/d was needed to increase 25(OH)D to adequacy (80–249 nmol/l) in >97·5 % of participants at 36 GW, while >85 µg/d was needed to reach this criterion at 4 weeks PP. The 25(OH)D increments from 20 to 36 GW and from 20 GW to 4 weeks PP diminished with supplemental dose and related inversely to 25(OH)D at 20 GW. Milk ARA related to vitamin D3 dose, but the infant adequate intake of 513 IU/l was not reached. Vitamin D3 dosages of 35 and >85 µg/d were needed to reach adequate maternal vitamin D status at 36 GW and 4 weeks PP, respectively. |
| Databáze: | OpenAIRE |
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