Crystal-proven Gout and Characteristic Gout Severity Factors Are Associated with Cardiovascular Disease
| Autor: | Sahel Zoakman, Hein J.E.M. Janssens, Jaap Fransen, Matthijs Janssen, Iris J.M. Disveld, Gerard A. Rongen, Laura B.E. Kienhorst |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Adult Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Gout Immunology Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Arthritis Disease Comorbidity Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Prevalence Immunology and Allergy Humans 030212 general & internal medicine Aged 030203 arthritis & rheumatology Acid level business.industry Confounding nutritional and metabolic diseases Middle Aged medicine.disease Uric Acid Serum urate Cross-Sectional Studies Cardiovascular Diseases Cohort Polyarthritis Female business |
| Zdroj: | The Journal of Rheumatology, 45, 6, pp. 858-863 The Journal of Rheumatology, 45, 858-863 |
| ISSN: | 0315-162X |
| Popis: | Objective.Our aim was to examine the prevalence of cardiovascular disease (CVD) in patients with crystal-proven gout compared to arthritis controls. Further, we analyzed the association between characteristic gout severity factors and CVD to provide further support for a pathogenetic relationship between gout and CVD.Methods.Patients with arthritis referred for diagnosis were consecutively included in the Gout Arnhem-Liemers cohort. Joint fluid analysis was performed in all referred patients; controls were negative for crystals. Patients’ characteristics and different manifestations of CVD and gout severity factors (disease duration, attack frequency, tophi, affected joints, high serum urate acid level, joint damage) were collected. Gout patients were compared with controls for the prevalence of CVD. In addition, the association between characteristic gout severity factors and presence of CVD was analyzed.Results.Data from 700 gout patients and 276 controls were collected. CVD was present in 47% (95% CI 44%–51%) and 24% (95% CI 19%–29%) of gout patients and controls, respectively. Corrected for confounders, gout was still strongly associated with an increased prevalence of CVD compared to controls (OR 3.39, 95% CI 2.37–4.84). In patients with gout, disease duration ≥ 2 years, oligo- or polyarthritis, serum urate acid > 0.55 mmol/l at presentation, and joint damage were independently (p < 0.05) associated with prevalent CVD.Conclusion.Crystal-proven gout was strongly associated with an increased prevalence of CVD. In patients with gout, characteristic gout severity factors were associated with CVD. |
| Databáze: | OpenAIRE |
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