Multicenter, prospective trial of white-light imaging alone versus white-light imaging followed by magnifying endoscopy with narrow-band imaging for the real-time imaging and diagnosis of invasion depth in superficial esophageal squamous cell carcinoma
| Autor: | Takaya Shimura, Takashi Joh, Satoshi Nomura, Takashi Mizushima, Keisuke Itoh, Masahide Ebi, Tomonori Yamada, Hiroshi Kanie, Hiroyasu Iwasaki, Kenji Murakami, Yoshikazu Hirata, Satoru Takahashi, Kenji Tsuchida, Hironobu Tsukamoto, Mika Kitagawa |
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| Rok vydání: | 2014 |
| Předmět: |
Invasion depth
Male medicine.medical_specialty Muscularis mucosae Esophageal Neoplasms Esophageal squamous cell carcinoma Gastroenterology Sensitivity and Specificity Narrow Band Imaging Esophagus Internal medicine Carcinoma medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Invasiveness Prospective Studies Prospective cohort study Aged Microscopy Mucous Membrane business.industry Magnifying endoscopy Cancer Middle Aged medicine.disease Clinical trial Carcinoma Squamous Cell Female Radiology Esophageal Squamous Cell Carcinoma Esophagoscopy business |
| Zdroj: | Gastrointestinal endoscopy. 81(6) |
| ISSN: | 1097-6779 |
| Popis: | Background Magnifying endoscopy with narrow-band imaging (ME-NBI) has been used to estimate the invasion depth of superficial esophageal squamous cell carcinoma (SESCC), but the real diagnostic power of ME-NBI remains unclear because of few prospective studies. Objectives To evaluate whether ME-NBI adds additional information to white-light imaging (WLI) for the diagnosis of invasion depth of SESCC. Design Multicenter, prospective trial using real-time imaging and diagnosis. Setting Seven Japanese institutions. Patients Fifty-five patients with SESCC were enrolled from June 2011 to October 2013, and the results for 49 lesions were analyzed. Interventions Patients underwent primary WLI followed by ME-NBI, and reports of primary WLI (WLI alone) were completed before secondary ME-NBI (WLI followed by ME-NBI). To standardize diagnosis among examiners, this trial was started after achievement of a mean κ value ≥ .6 among 11 participating endoscopists. Main Outcome Measurements Diagnosis of invasion depth by each tool was divided into cancer limited to the epithelium and the lamina propria mucosa and cancer invading beyond the muscularis mucosae (≥T1a-MM) and then collated with the final pathologic diagnosis by an independent pathologist blinded to the clinical data. Results The accuracy of invasion depth in WLI alone and WLI followed by ME-NBI was 71.4% and 65.3% ( P = .375), respectively. Sensitivity for ≥T1a-MM was 61.1% for both groups ( P = 1.000), and specificity for ≥T1a-MM was 77.4% for WLI alone and 67.7% for WLI followed by ME-NBI ( P = .375). Limitation Open-label trial. Conclusions ME-NBI showed no additional benefit to WLI for diagnosis of invasion depth of SESCC. (University Hospital Network Clinical Trials Registry number: UMIN000005632.) |
| Databáze: | OpenAIRE |
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