Dry eye symptoms in interferon regulatory factor 3-deficient mice due to herpes simplex virus infection in harderian gland and lacrimal gland
| Autor: | Jing-Yi Zhu, Xi Zhang, Xiao Zheng, Lin-Lin Luo, Cheng-Yi Mao, Sen Lin, Jian Ye |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Harderian Gland
Lacrimal Apparatus Herpes Simplex Herpesvirus 1 Human Sensory Systems Cornea Disease Models Animal Mice Phosphatidylinositol 3-Kinases Cellular and Molecular Neuroscience Ophthalmology Keratitis Herpetic Animals Dry Eye Syndromes Interferon Regulatory Factor-3 RNA Messenger Proto-Oncogene Proteins c-akt |
| Zdroj: | Experimental Eye Research. 219:109053 |
| ISSN: | 0014-4835 |
| DOI: | 10.1016/j.exer.2022.109053 |
| Popis: | Dry eye syndrome (DES) is a multifactorial ocular disorder. The possible pathogens and pathogenic mechanisms for virus-related dry eye disease are largely unknown. The current study aimed to provide evidence for mechanisms contributing to DES induced by herpes simplex virus (HSV) infection in the harderian gland (HG) and lacrimal gland (LG).We recorded the dry eye-like cornea pathology of irf3Inoculated irf3We observed evidence of DES in irf3 |
| Databáze: | OpenAIRE |
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