The effect of some topically administered C18-, C19- and C21-steroids and a dodecahydrophenanthrene on human sebum production
| Autor: | J. Tamm, U. Volkwein, Erich Ludwig |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Sebaceous gland medicine.medical_specialty Time Factors Administration Topical Sebum production Dermatology Sebaceous Glands chemistry.chemical_compound Internal medicine Animals Humans Medicine Testosterone Progesterone Retroprogesterone business.industry Epitestosterone Dihydrotestosterone General Medicine Phenanthrenes Rats Allyl Compounds Sebum Endocrinology medicine.anatomical_structure chemistry Allylestrenol Female Steroids business medicine.drug |
| Zdroj: | Archiv f�r Dermatologische Forschung. 249:29-34 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/bf00595278 |
| Popis: | The effects of topically applied steroids and of a dodecahydrophenanthrene were investigated by means of the sebaceous gland response. Compared with testosterone (= 1) the effects of 5α-dihydrotestosterone and 5β-dihydrotestosterone were found to be 0.6 and 0.26, respectively. Epitestosterone was ineffective in females, whereas in some males an increase in sebum production was observed. The following steroids showed no significant effects with regard to an inhibition of sebum production: Retroprogesterone (Duphaston), 17α-allyl-retrotestosterone, allylestrenol, Δ1-6-chloro-retroprogesterone. The nonsteroid Ro 5-2537 [2-(1-ethinyl-1-hydroxyethyl)-7-oxo-1, 2,3,4,4α,4β,5,6,7,9,10,10α-dodecahydrophenanthrene]-caused in all subjects a significant decrease in sebum production. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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