Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study

Autor: Joji Ishikawa, Keigo Shimoji, Kazuhito Oba, Remi Kodera, Atsushi Araki, Kenji Toyoshima, Yoshiaki Tamura, Yuko Chiba, Aya Tachibana, Aya M. Tokumaru
Rok vydání: 2020
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 12, Iss 4, Pp 633-640 (2021)
Journal of Diabetes Investigation
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13379
Popis: Aims/Introduction Older adults with diabetes mellitus are susceptible to sarcopenia. Diffusion tensor imaging studies have also shown that patients with diabetes have altered white matter integrity. However, the relationship between these structural changes in white matter and sarcopenia remains poorly understood. Materials and Methods The study included 284 older patients (aged ≥65 years) who visited the Tokyo Metropolitan Geriatric Hospital Frailty Clinic. We used diffusion tensor imaging to measure fractional anisotropy (FA) and mean diffusivity (MD) to evaluate changes in white matter integrity. We investigated the associations between sarcopenia, or its diagnostic components, and FA or MD in seven white matter tracts considered to be associated with sarcopenia according to the patients’ diabetes status. Results We found significantly low FA or high MD values in the bilateral anterior thalamic radiations (ATR) and right inferior fronto‐occipital fasciculus (IFOF) of patients with Asian Working Group for Sarcopenia 2019‐defined sarcopenia, in all patients and those with diabetes. Using binominal regression analyses, we associated low FA values in the left ATR and right IFOF with sarcopenia in all patients and those with diabetes, after adjusting for age, gender, HbA1c, blood pressure, cognitive function, physical activity, depression, nutritional status, and inflammation. Conclusions White matter alterations in left ATR and right IFOF are associated with the prevalence of sarcopenia in patients with diabetes. Specific changes to the left ATR and right IFOF tracts could play critical roles in the occurrence of sarcopenia in patients with diabetes.
Older adults with diabetes mellitus are susceptible to sarcopenia and altered white matter integrity. Using diffusion tensor imaging technique, we found alterations in left anterior thalamic radiation and right inferior fronto‐occipital fasciculus are associated with sarcopenia in patients with diabetes.
Databáze: OpenAIRE