Associations between sarcopenia and white matter alterations in older adults with diabetes mellitus: A diffusion tensor imaging study
Autor: | Joji Ishikawa, Keigo Shimoji, Kazuhito Oba, Remi Kodera, Atsushi Araki, Kenji Toyoshima, Yoshiaki Tamura, Yuko Chiba, Aya Tachibana, Aya M. Tokumaru |
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Rok vydání: | 2020 |
Předmět: |
Male
Sarcopenia medicine.medical_specialty Endocrinology Diabetes and Metabolism Diseases of the endocrine glands. Clinical endocrinology Cohort Studies Diabetes Complications White matter 03 medical and health sciences Diabetes mellitus 0302 clinical medicine Internal medicine Fractional anisotropy Prevalence Internal Medicine medicine Humans 030212 general & internal medicine Tokyo Depression (differential diagnoses) Aged Aged 80 and over White matter alterations business.industry Articles General Medicine RC648-665 musculoskeletal system medicine.disease White Matter Clinical Science and Care Diffusion tensor imaging medicine.anatomical_structure Blood pressure Original Article Female business human activities 030217 neurology & neurosurgery Diffusion MRI |
Zdroj: | Journal of Diabetes Investigation, Vol 12, Iss 4, Pp 633-640 (2021) Journal of Diabetes Investigation |
ISSN: | 2040-1124 2040-1116 |
DOI: | 10.1111/jdi.13379 |
Popis: | Aims/Introduction Older adults with diabetes mellitus are susceptible to sarcopenia. Diffusion tensor imaging studies have also shown that patients with diabetes have altered white matter integrity. However, the relationship between these structural changes in white matter and sarcopenia remains poorly understood. Materials and Methods The study included 284 older patients (aged ≥65 years) who visited the Tokyo Metropolitan Geriatric Hospital Frailty Clinic. We used diffusion tensor imaging to measure fractional anisotropy (FA) and mean diffusivity (MD) to evaluate changes in white matter integrity. We investigated the associations between sarcopenia, or its diagnostic components, and FA or MD in seven white matter tracts considered to be associated with sarcopenia according to the patients’ diabetes status. Results We found significantly low FA or high MD values in the bilateral anterior thalamic radiations (ATR) and right inferior fronto‐occipital fasciculus (IFOF) of patients with Asian Working Group for Sarcopenia 2019‐defined sarcopenia, in all patients and those with diabetes. Using binominal regression analyses, we associated low FA values in the left ATR and right IFOF with sarcopenia in all patients and those with diabetes, after adjusting for age, gender, HbA1c, blood pressure, cognitive function, physical activity, depression, nutritional status, and inflammation. Conclusions White matter alterations in left ATR and right IFOF are associated with the prevalence of sarcopenia in patients with diabetes. Specific changes to the left ATR and right IFOF tracts could play critical roles in the occurrence of sarcopenia in patients with diabetes. Older adults with diabetes mellitus are susceptible to sarcopenia and altered white matter integrity. Using diffusion tensor imaging technique, we found alterations in left anterior thalamic radiation and right inferior fronto‐occipital fasciculus are associated with sarcopenia in patients with diabetes. |
Databáze: | OpenAIRE |
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