Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke

Autor: David Bonifačić, Vlatka Sotošek Tokmadžić, Indira Benjak, Andrica Lekić, Natalia Kučić, Adrian Toplak
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences
Pathology
medicine.medical_specialty
Disease outcome
Gastroenterology
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Monocytes
Proinflammatory cytokine
03 medical and health sciences
Leukocyte Count
0302 clinical medicine
Modified Rankin Scale
Internal medicine
ischemic stroke
Medicine
Humans
In patient
cardiovascular diseases
Chemokine CCL2
Aged
Aged
80 and over
business.industry
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti
Monocyte
BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences
Reproducibility of Results
monocyte chemoattractant protein 1
General Medicine
Prognosis
nervous system diseases
Stroke
030104 developmental biology
medicine.anatomical_structure
Apoptosis
Ischemic stroke
Female
monocytes
BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti
business
030217 neurology & neurosurgery
Biomarkers
Monocyte chemoattractant protein
Zdroj: Wiener klinische Wochenschrift
Volume 128
Issue 1/2
ISSN: 0043-5325
Popis: In this study to identify prognostic biomarkers for ischemic stroke (IS) outcome, we monitored monocyte number and monocyte chemoattractant protein (MCP-1) concentration in peripheral blood of 44 patients with IS during the week following IS. According to the severity of IS, patients were allocated to three groups: patients with transient ischemic attack (TIA), patients with National Institute of Health Stroke Scale (NIHSS) score ≤ 12, and patients with NIHSS > 12. In patients with NIHSS > 12 statistically significant increased number of monocytes was observed on day 7. MCP-1 plasma concentration initially increased, decreased at day 3 in patients with NIHSS > 12 and increased and restored on day 7. A negative correlation between the number of monocytes and MCP-1 concentration was observed on day 3 after IS. Higher day-7 MCP-1 level was associated with higher modified Rankin Scale (mRS) value (indicating worse outcome) at 90 days post-IS in patients with NIHSS > 12. Our findings suggest that number of monocytes and plasma MCP-1 level could be clinical prognostic biomarkers as early predictors of disease outcome in patients with IS.
Databáze: OpenAIRE
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