Bioconcentration and Metabolism of Pyriproxyfen in Tadpoles of African Clawed Frogs, Xenopus laevis
| Autor: | Toshiyuki Katagi, Keiko Ose, Mitsugu Miyamoto, Takuo Fujisawa |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Amphibian African clawed frog medicine.medical_specialty Pyridines 0211 other engineering and technologies Xenopus Bioconcentration 02 engineering and technology 010501 environmental sciences Biology 01 natural sciences Hydroxylation Toxicology Xenopus laevis chemistry.chemical_compound biology.animal Internal medicine medicine Animals 0105 earth and related environmental sciences 021110 strategic defence & security studies Gastrointestinal tract General Chemistry Metabolism biology.organism_classification Endocrinology chemistry Larva Female Pyriproxyfen General Agricultural and Biological Sciences Water Pollutants Chemical Half-Life |
| Zdroj: | Journal of Agricultural and Food Chemistry. 65:9980-9986 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | Bioconcentration and metabolism of pyriproxyfen uniformly labeled with 14C at the phenoxyphenyl ring were studied using tadpoles of African clawed frog, Xenopus laevis, exposed to water at the nominal concentrations of 3 and 300 ppb for 22 days under the flow-through conditions, with a following 3 day depuration phase. Neither meaningful mortality nor abnormal behavior was observed in control and exposure groups throughout the study. After the rapid uptake to tadpoles, pyriproxyfen was extensively metabolized and excreted, and as a result, steady-state bioconcentration factors and depuration half-lives ranged from 550 to 610 and from 0.34 to 0.54 days, respectively. The metabolites were mostly distributed in the liver or gastrointestinal tract. The major metabolic reactions were hydroxylation at the 4′ position of the phenoxyphenyl group and cleavage of the ether linkage, followed by sulfate conjugation. |
| Databáze: | OpenAIRE |
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