Potential Short-Term Air Pollution Effects on Rheumatoid Arthritis Activity in Metropolitan Areas in the North of Italy: A Cross-Sectional Study
| Autor: | Simona Iodice, Orazio De Lucia, Tommaso Schioppo, Roberto Caporali, Ennio Giulio Favalli, Antonella Murgo, Valentina Bollati, Francesca Ingegnoli, Valentina Longo, Tania Ubiali |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
rheumatoid arthritis
Healthcare use Cross-sectional study Health Toxicology and Mutagenesis Nitrogen Dioxide air pollution Air pollution medicine.disease_cause Article Disease activity Arthritis Rheumatoid Ozone Environmental health Medicine Humans particulate matter Air Pollutants Air pollutant concentrations business.industry Public Health Environmental and Occupational Health Environmental Exposure medicine.disease Cross-Sectional Studies Rheumatoid arthritis disease activity Joint damage Partially able business |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 8490, p 8490 (2021) International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health; Volume 18; Issue 16; Pages: 8490 |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Rheumatoid arthritis (RA) flare is related to increased joint damage, disability, and healthcare use. The impact of short-term air pollution exposure on RA disease activity is still a matter of debate. In this cross-sectional study, we investigated whether short-term exposure to particulate matter (PM)10, PM2.5, nitrogen dioxide (NO2), and ozone (O3) affected RA disease activity (DAS28 and SDAI) in 422 consecutive RA residents in Lombardy, North of Italy. Air pollutant concentrations, estimated by Regional Environmental Protection Agency (Lombardy—Italy) at the municipality level, were used to assign short-term exposure from the day of enrolment, back to seven days. Some significant negative associations emerged between RA disease activity, PM10, and NO2, whereas some positive associations were observed for O3. Patients were also stratified according to their ongoing Disease-Modifying anti-Rheumatic Drugs (DMARDs) treatment: no DMARDs (n = 25), conventional synthetic DMARDs (n = 108), and biological or targeted synthetic DMARDs (n = 289). Therapy interaction seemed partially able to influence the relationship between short-term air pollution exposure and RA disease activity (PM2.5 levels and DAS28 at the day of the visit-O3 levels and disease activity scores for the seven days before the evaluation). According to our results, the impact of short-term air pollution exposure (seven days) minimally impacts disease activity. Moreover, our study suggests therapy could alter the response to environmental factors. Further evidence is needed to elucidate determinants of RA flare and its management. |
| Databáze: | OpenAIRE |
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