Baccharis trimera (Carqueja) Improves metabolic and redox status in an experimental model of type 1 diabetes
| Autor: | Maria Lúcia Pedrosa, Marcelo Eustáquio Silva, Joamyr Victor Rossoni Júnior, Daniela Caldeira Costa, Jason G. Taylor, Glaucy Rodrigues de Araújo, Natália Nogueira do Nascimento Kaut, Míriam Martins Chaves, Ana Carolina Silveira Rabelo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Antioxidant
Article Subject medicine.medical_treatment Pharmacology medicine.disease_cause 030226 pharmacology & pharmacy Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Alloxan medicine chemistry.chemical_classification Type 1 diabetes biology Glutathione peroxidase lcsh:Other systems of medicine lcsh:RZ201-999 medicine.disease Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis biology.protein Liver function Oxidative stress Research Article |
| Zdroj: | Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP Evidence-Based Complementary and Alternative Medicine, Vol 2018 (2018) Evidence-based Complementary and Alternative Medicine : eCAM |
| Popis: | Diabetes mellitus is a metabolic disorder that causes severe complications due to the increased oxidative stress induced by disease. Many plants are popularly used in the treatment of diabetes, e.g., Baccharis trimera (carqueja). The aim of this study was to explore the potential application of the B. trimera hydroethanolic extract in preventing redox stress induced by diabetes and its hypoglycemic properties. Experiments were conducted with 48 female rats, divided into 6 groups, named C (control), C600 (control + extract 600 mg/kg), C1200 (control + extract 1200 mg/kg), D (diabetic), D600 (diabetic + 600 mg/kg), and D1200 (diabetic + 1200 mg/kg). Type 1 diabetes was induced with alloxan, and the animals presented hyperglycemia and reduction in insulin and body weight. After seven days of experimentation, the nontreated diabetic group showed changes in biochemical parameters (urea, triacylglycerol, alanine aminotransferase, and aspartate aminotransferase) and increased carbonyl protein levels. Regarding the antioxidant enzymes, an increase in superoxide dismutase activity was observed but in comparison a decrease in catalase and glutathione peroxidase activity was noted which suggests that diabetic rats suffered redox stress. In addition, the mRNA of superoxide dismutase, catalase, and glutathione peroxidase enzymes were altered. Treatment of diabetic rats with B. trimera extract resulted in an improved glycemic profile and liver function, decreased oxidative damage, and altered the expression of mRNA of the antioxidants enzymes. These results together suggest that B. trimera hydroethanolic extract has a protective effect against diabetes. |
| Databáze: | OpenAIRE |
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