Aberrant connections between climbing fibres and Purkinje cells induce alterations in the timing of an instrumental response in the rat
| Autor: | María Esther Olvera-Cortés, Miguel Angel Guevara, Miguel Ángel López-Vázquez, Lorena Gaytán-Tocavén |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Cerebellum Purkinje cell Striatum Olivary Nucleus Serial Learning Receptors N-Methyl-D-Aspartate Rats Sprague-Dawley Synapse Purkinje Cells 03 medical and health sciences 0302 clinical medicine medicine Animals Learning Behavior Animal General Neuroscience Antagonist Axons Rats 030104 developmental biology medicine.anatomical_structure nervous system Climbing Synapses Time Perception Conditioning Operant NMDA receptor Sequence learning Dizocilpine Maleate Psychology Excitatory Amino Acid Antagonists Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Experimental Brain Research. 235:2787-2796 |
| ISSN: | 1432-1106 0014-4819 |
| DOI: | 10.1007/s00221-017-5014-4 |
| Popis: | Cerebellar participation in timing and sensory-motor sequences has been supported by several experimental and clinical studies. A relevant role of the cerebellum in timing of conditioned responses in the range of milliseconds has been demonstrated, but less is known regarding the role of the cerebellum in supra-second timing of operant responses. A dissociated role of the cerebellum and striatum in timing in the millisecond and second range had been reported, respectively. The climbing fibre-Purkinje cell synapse is crucial in timing models; thus, the aberrant connection between these cellular elements is a suitable model for evaluating the contribution of the cerebellum in timing in the supra-second range. The aberrant connection between climbing fibres and Purkinje cells was induced by administration of the antagonist of NMDA receptors MK-801 to Sprague-Dawley rats at postnatal days 7-14. The timing of an operant response with two fixed intervals (5 and 8 s) and egocentric sequential learning was evaluated in 60-day-old adult rats. The aberrant connections caused a reduced accuracy in the timing of the instrumental response that was more evident in the 8-s interval and a reduced number of successive correct responses (responses emitted in the correct second without any other response between them) in the 8-s interval. In addition, an inability to incorporate new information in a sequence previously learned in egocentric-based sequence learning was apparent in rats with aberrant CF-PC synapses. These results support a relevant role for the cerebellum in the fine-tuning of the timing of operant responses in the supra-second range. |
| Databáze: | OpenAIRE |
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