MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk
| Autor: | Ricky O'Brien, Vincent Caillet, Kathryn Szymura, Paul J. Keall, Nicholas Hardcastle, Jeremy T. Booth, E. Colvill |
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| Rok vydání: | 2016 |
| Předmět: |
Organs at Risk
medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Planning target volume SABR volatility model Tracking (particle physics) Radiosurgery Imaging phantom 029903 - Medical Physics [FoR] 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung medicine Humans Radiology Nuclear Medicine and imaging Lung tumour Lung Mean lung dose business.industry Phantoms Imaging Radiotherapy Planning Computer-Assisted Dose-Response Relationship Radiation Radiotherapy Dosage Hematology Radiation therapy medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Respiratory Mechanics MLC tracking Radiology Particle Accelerators Nuclear medicine business |
| Zdroj: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 124(1) |
| ISSN: | 1879-0887 |
| Popis: | Purpose Assess the dosimetric impact of multi-leaf collimator (MLC) tracking and mid-ventilation (midV) planning compared with the internal target volume (ITV)-based planning approach for lung Stereotactic Ablative Body Radiotherapy (SABR). Method Ten lung SABR patients originally treated with an ITV-based plan were re-planned according to MLC tracking and midV planning schemes. All plans were delivered on a linac to a motion phantom in a simulated treatment with real lung motions. Delivered dose was reconstructed in patient planning scans. ITV-based, tracking and midV regimes were compared at the planning and delivered stages based on PTV volume and dose metrics for the GTV and OAR. Results MLC tracking and midV schemes yielded favourable outcomes compared with ITV-based plans. Average reduction in PTV volume was (MLC tracking/MidV) 33.9%/22%. GTV dose coverage performed better with MLC tracking than the other regimes. Reduction in dose to OAR were for the lung (mean lung dose, 0.8 Gy/0.2 Gy), oesophagus (D3 cc, 1.9 Gy/1.4 Gy), great vessels (D10 cc, 3.2 Gy/1.3 Gy), trachea (D4 cc, 1.1 Gy/0.9 Gy), heart (D1 cc, 2.0 Gy/0.5 Gy) and spinal cord (D0.03 cc, 0.5 Gy/−0.1 Gy). Conclusion MLC tracking showed reduction in PTV volume, superior GTV dose coverage and organ dose sparing than MidV and ITV-based strategies. |
| Databáze: | OpenAIRE |
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