Provirus Load in Patients with Human T-Cell Leukemia Virus Type 1 Uveitis Correlates with Precedent Graves' Disease and Disease Activities
| Autor: | Takashi Sawada, Ayako Ono, Masao Matsuoka, Kazunari Yamaguchi, Shinkan Tokudome, Sumitaka Yamane, Eiko Ikeda, Manabu Mochizuki, Toshiki Watanabe |
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| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
Graves' disease HTLV‐1 uveitis Polymerase Chain Reaction Peripheral blood mononuclear cell Article Virus Uveitis Disease activities Proviruses Immunopathology sIL‐2R medicine Humans Provirus load Human T-lymphotropic virus 1 biology business.industry Receptors Interleukin-2 Viral Load Provirus medicine.disease key words Graves Disease HTLV-I Antibodies Leukemia Oncology Immunology biology.protein Antibody business Viral load |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| DOI: | 10.1111/j.1349-7006.1998.tb03262.x |
| Popis: | We previously demonstrated the increased provirus load in the peripheral blood of patients with human T‐cell leukemia virus type 1 (HTLV‐1) uveitis (HU). To delineate the relevance of the increased provirus load to clinical and immunologic parameters, we studied the correlation between them. Seventy‐nine HU patients (24 male and 55 female) were included in the study, with their informed consent. Plasma samples and genomic DNA of the peripheral blood mononuclear cells were isolated and the provirus load was estimated by semi‐quantitative polymerase chain reaction of the gag region sequence. Serum levels of anti‐HTLV‐1 antibodies and soluble IL‐2R were determined by electrochemiluminescence immuno assay and by ELISA, respectively. Disease activities were assessed and graded 0 to 4 according to the evaluation system. Recurrence of the disease during the follow‐up period was diagnosed ophthalmologically. The provirus load was significantly higher in the HU patients after Graves' disease (GD) than in those without GD (P |
| Databáze: | OpenAIRE |
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