Capsule endoscopy findings in patients with established and suspected small-bowel Crohn's disease: correlation with radiologic, endoscopic, and histologic findings
| Autor: | Shou-Jiang Tang, Geoffrey W. Gardiner, Rima Petroniene, Jeffrey P. Baker, Khursheed N. Jeejeebhoy, Elena Dubcenco, Arthur H. Zalev |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Biopsy Radiography medicine.medical_treatment Enema Methylcellulose Gastroenterology Endoscopy Gastrointestinal law.invention Diagnosis Differential Crohn Disease Ileum Predictive Value of Tests Capsule endoscopy law Internal medicine medicine Humans Telemetry Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Crohn's disease medicine.diagnostic_test business.industry Reproducibility of Results Ileitis medicine.disease digestive system diseases Endoscopy Predictive value of tests Female business Follow-Up Studies |
| Zdroj: | Gastrointestinal Endoscopy. 62:538-544 |
| ISSN: | 0016-5107 |
| DOI: | 10.1016/j.gie.2005.06.026 |
| Popis: | Background Little is known about the accuracy of capsule endoscopy (CE) in evaluation of small-bowel Crohn's disease. Methods Symptomatic eligible patients had ileocolonoscopy and biopsies from the terminal ileum, followed by small-bowel radiologic studies before CE. Endoscopic, radiologic, CE, and histologic findings were compared. Histology (terminal ileum biopsy specimens or a tissue sample after small-bowel resection) served as a criterion standard. Results Fifty-four patients were enrolled; 15 of the 54 patients were excluded from data analysis (critical small-bowel strictures, 14, identified on radiology; incomplete CE, 1). Data were analyzed for 39 patients. All patients had histologic evaluation of the small bowel. Final diagnosis of active small-intestine Crohn's disease was made in 29/39 patients (74.4%). When calculated, CE yielded a sensitivity and a specificity of 89.6% and 100.0%, respectively, and a positive predictive value and a negative predictive value of 100.0% and 76.9%, respectively, whereas small-bowel series were 27.6%/100.0% and 100.0%/32.3%. Conclusions CE is more accurate in detecting small-bowel inflammatory changes suggestive of Crohn's disease than conventional studies. CE, combined with ileocolonoscopy, may be proposed as a first-line investigation of the small intestine in cases of uncomplicated known or suspected Crohn's disease. |
| Databáze: | OpenAIRE |
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