Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans

Autor: Meddly Santollala, Victor Borda, Carolina Silva-Carvalho, Rennan G. Moreira, Isabela Alvim, Lucas Michelin, Luis Jaramillo-Valverde, Murilo Pita-Oliveira, Fernanda S G Kehdy, Mariana Scudeler, Ricardo A. Verdugo, Timothy D. O’Connor, Andres Vasquez-Dominguez, Giordano B. Soares-Souza, Fernanda Rodrigues-Soares, Heinner Guio, Eduardo Tarazona-Santos, Vinicius Furlan, Cesar Neira, Sabrina Torres-Loureiro, Marla M. Aquino, Thiago P. Leal, Renato Santana Aguiar, Camila Zolini
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Genetics and Molecular Biology, Vol 44, Iss 1 suppl 1 (2021)
Genetics and Molecular Biology
Genetics and Molecular Biology, Volume: 44, Issue: 1 Supplement 1, Article number: e20200484, Published: 25 AUG 2021
ISSN: 1678-4685
Popis: The current search for host-susceptibility variants for COVID-19 contrasts with the fact that the study of the genetic architecture of Severe Acute Respiratory Syndrome (SARS) has been neglected. For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is only one convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population genetics and of sequencing data in the design of genetic association studies in different human populations: the high linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific. Leveraging on a combination of genotyping and sequencing data for Native Americans (neglected in genetic studies), we show that while their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the highest worldwide, it is not in LD with the eQTL rs383510, that therefore, should be directly genotyped in genetic association studies of SARS in populations with Native American ancestry.
Databáze: OpenAIRE
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