Acute embryonic exposure of zebrafish to permethrin induces behavioral changes related to anxiety and aggressiveness in adulthood
| Autor: | Patrícia de Brum Vieira, Lucia Emanueli Schimith, M. Santer, D. G. Costa-Silva, Luana Paganotto Leandro, F.V.M. Nunes, Jeferson Luis Franco, Mauro Eugênio Medina Nunes, R.S. De Mello, Illana Kemmerich Martins, Thaís Posser |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Insecticides Embryo Nonmammalian animal structures Anxiety Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Pyrethrins medicine Animals Zebrafish Permethrin Biological Psychiatry Larva Thigmotaxis Pyrethroid Behavior Animal biology fungi Embryo biology.organism_classification medicine.disease 030227 psychiatry Aggression Disease Models Animal Psychiatry and Mental health chemistry Neurodevelopmental Disorders Prenatal Exposure Delayed Effects embryonic structures Female medicine.symptom 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychiatric Research. 121:91-100 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2019.11.006 |
| Popis: | Permethrin (PM) is one of the most used synthetic pyrethroid worldwide. Exposure to this compound during pregnancy and early childhood has been indicated as a risk factor for neurodevelopmental disorders. We evaluated the long-term effects of embryonic PM exposure in different stages of zebrafish development. Briefly, embryos (3 hpf) were exposed to sub-lethal concentrations of PM (25 and 50 μg.L−1) during 24 h and then behavioral parameters were evaluated during embryonic (28 hpf), eleutheroembryonic (3 dpf), larval (7 dpf), and adult stages (90 dpf). PM exposure decreased spontaneous movement at 28 hpf and decreased thigmotaxis in eleutheroembryos. The long-term effects of PM include changes in non-motor behaviors such as fear and anxiety in larva and adults. Adults embryonically exposed to PM also showed a significant increase in aggressiveness parameters. These results demonstrated that embryonic exposure to PM induces persistent neurotoxic effects in adulthood, which can impair the cognitive and behavioral fitness of non-target species contributing to a rise in neurodevelopmental disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect