Variant genotypes of MDR1 C3435T increase the risk of leukemia: evidence from 10 case–control studies
| Autor: | Zhibin Hu, Songyu Cao, Xifeng Qian, Yun-Feng Shen, Jing Dong, Guohua Yang, Guangfu Jin |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Genotype Chronic lymphocytic leukemia Polymorphism Single Nucleotide Risk Factors Polymorphism (computer science) Internal medicine medicine Humans Genetic Predisposition to Disease ATP Binding Cassette Transporter Subfamily B Member 1 Child Acute leukemia Leukemia business.industry Case-control study Hematology Odds ratio medicine.disease Confidence interval Chronic leukemia Case-Control Studies Immunology business |
| Zdroj: | Leukemia & Lymphoma. 53:1183-1187 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428194.2011.641179 |
| Popis: | The C3435T (Ile1142Ile) polymorphism of the multidrug resistance gene (MDR1) has been implicated in leukemia risk, but the reported results are inconsistent. Here we performed a meta-analysis to evaluate the association between C3435T polymorphism and the risk of leukemia using all case-control studies published before June 2011 according to PubMed. A total of 10 case-control studies were included in this analysis. We found that variant genotypes of C3435T (CT/TT) were significantly associated with an increased risk of leukemia (CT/TT vs. CC: odds ratio [OR] = 1.29; 95% confidence interval [CI] = 1.11-1.50, p = 0.284 for heterogeneity test). Additionally, the association was more significant in chronic leukemia (specifically B-cell chronic lymphocytic leukemia [B-CLL]) (OR = 1.94; 95% CI = 1.32-2.85, p = 0.648 for heterogeneity test) than in acute leukemia (OR = 1.19; 95% CI = 1.01-1.40, p = 0.616 for heterogeneity test), p = 0.021 for heterogeneity test between groups. These findings provide further evidence that the MDR1 C3435T variant may modify the susceptibility to leukemia. |
| Databáze: | OpenAIRE |
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