ANTIMICROBIAL EFFECT OF ORGANOTIN COMPOUNDS DERIVED FROM PHENOLIC SCHIFF BASES
| Autor: | Ane Francielly da Silva Santos, José Roberto da Silveira Maia |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Schiff base
biology Characterization Bacillus subtilis HEXA medicine.disease_cause biology.organism_classification Metal chemistry.chemical_compound Organotin(IV) compounds Monomer Antimicrobial effect chemistry Staphylococcus aureus visual_art visual_art.visual_art_medium medicine Bactericide Methanol Escherichia coli Nuclear chemistry |
| Zdroj: | The Journal of Engineering and Exact Sciences; Vol. 5 No. 5 (2019); 0452-0459 The Journal of Engineering and Exact Sciences; Vol. 5 Núm. 5 (2019); 0452-0459 The Journal of Engineering and Exact Sciences; v. 5 n. 5 (2019); 0452-0459 The Journal of Engineering and Exact Sciences Universidade Federal de Viçosa (UFV) instacron:UFV |
| ISSN: | 2527-1075 0452-0459 |
| Popis: | Several organotin(IV) derivatives of phenolic Schiff bases were prepared and investigated by spectroscopic methods. These compounds were bioassayed to evaluate their bacterial effect against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Salmonella typhimurium) microorganisms. Dimeric and monomeric compounds were characterized by infrared in solid state. Metallic centers having penta-, hexa-, and heptacoordination were identified by multinuclear NMR (1H, 13C and 119Sn) in solution. The di- and triorganotin(IV) derivatives were also investigated by conductimetric measurements in methanol, elemental analysis and melting point. The bioassay of these tin(IV) compounds showed that the best resulting activity was against S. aureus for the triphenyltin(IV) phenolic Schiff base derivatives, presenting MICs of 1.1 µM (0.6 mg mL-1) and 2.2 µM (1.3 mg mL-1). |
| Databáze: | OpenAIRE |
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