A controller for automatic regulation of induced paralysis during surgery
| Autor: | Khosrow Behbehani, Deepak Ramakrishna, Kevin W. Klein |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Offset (computer science) Adaptive control Automatic control Computer science Biomedical Engineering Models Biological Intraoperative Period Control theory Anesthesiology medicine Paralysis Humans Computer Simulation Infusions Intravenous Decision Making Computer-Assisted Monitoring Physiologic Supervisor Vecuronium Bromide Surgery Nonlinear system Nonlinear Dynamics Vecuronium bromide medicine.symptom Algorithms medicine.drug |
| Zdroj: | Annals of biomedical engineering. 22(2) |
| ISSN: | 0090-6964 |
| Popis: | This paper presents a strategy for automatic control of induced paralysis using vecuronium bromide during surgery. The controller is self-tuning and adapts to inter-patient and intra-patient response variations while optimizing the output variance and infusion rate. In particular, the controller is capable of accommodating the variations of pure time delays in patient response. The performance of the controller is evaluated using an experimentally derived pharmacokinetic and nonlinear pharmacodynamic model of patient response. The results indicate that the controller provides robust regulation of the paralysis level with no output offset. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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